Pentelute Lab MIT | Pentelute Lab MIT - Publications Page

The Pentelute Lab leverages expertise in peptide chemistry, molecular biology, and technology development to create peptide and protein-based therapeutics and tools for chemical biology.

Pentelute Lab, MIT, Cambridge, Chemistry, Molecular biology, technology development, peptide, protein-based therapeutics, chemical Biology, Bradley Pentelute

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PUBLICATIONS

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2012
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2014
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2016
2017
Publications

Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

2017, Publications

Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

2017, Publications

Heterochiral Knottin Protein: Folding and Solution Structure

2017, Publications

Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries

2017, Publications

Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

2017, Publications

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

2017, Publications

Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase

2017, Publications

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

2017, Publications

A fully automated flow-based approach for accelerated peptide synthesis

2017, Publications

Palladium-Mediated Arylation of Lysine in Unprotected Peptides

2017, Publications

Salt Effect Accelerates Site-Selective Cysteine Bioconjugation

2016, Publications

d-Amino Acid Scan of Two Small Proteins

2016, Publications

Nitrogen Arylation for Macrocyclization of Unprotected Peptides

2016, Publications

Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin

2016, Publications

Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates

2016, Publications

C-Terminal Modification of Fully Unprotected Peptide Hydrazides via in Situ Generation of Isocyanates

2016, Publications

Macrocyclization of Unprotected Peptide Isocyanates

2016, Publications

A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis

2016, Publications

π-Clamp-mediated cysteine conjugation

2015, Publications

A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway

2015, Publications

Organometallic palladium reagents for cysteine bioconjugation

2015, Publications

An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides.

2015, Publications

Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen

2015, Publications

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

2015, Publications

Atomic structure of anthrax protective antigen pore elucidates toxin translocation.

2015, Publications

Total Synthesis and Biochemical Characterization of Mirror Image Barnase

2015, Publications

Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs

2015, Publications

Delivery of mirror image polypeptides into cells

2014, Publications

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen

2014, Publications

Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides

2014, Publications

Flow-Based Enzymatic Ligation via Sortase A

2014, Publications

Rapid Total Synthesis of DARPin pE59 and Barnase

2014, Publications

Rapid Flow-Based Peptide Synthesis

2014, Publications

Convergent Diversity-Oriented Side-Chain Macrocyclization Scan for Unprotected Polypeptides

2014, Publications

Enzymatic “Click” Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase

2013, Publications

Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance.

2013, Publications

A Perfluoroaryl-Cysteine Chemistry Approach to Unprotected Peptide Stapling

2013, Publications

Three Dimensional Structure of the Anthrax Toxin Translocon–lethal Factor Complex by Cryo-electron Microscopy

2013, Publications

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

2013, Publications

Assembly of Anthrax Toxin Pore: Lethal-factor Complexes into Lipid Nanodiscs.

2013, Publications

Protein Thioester Synthesis Enabled By: Sortase

2012, Publications