Pentelute Lab MIT | Pentelute Lab MIT - Publications Page

The Pentelute Lab leverages expertise in peptide chemistry, molecular biology, and technology development to create peptide and protein-based therapeutics and tools for chemical biology.

Pentelute Lab, MIT, Cambridge, Chemistry, Molecular biology, technology development, peptide, protein-based therapeutics, chemical Biology, Bradley Pentelute

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PUBLICATIONS

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2017
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2019
2020
Publications

A Platinum(IV) Prodrug—Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain

2020, Publications

Conformational Dynamics in Extended RGD-Containing Peptides

2020, Publications

Ultra-large chemical libraries for the discovery of high-affinity peptide binders

2020, Publications

Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids

2020, Publications

Synthesis of proteins by automated flow chemistry

2020, Publications

Protein–Protein Cross-Coupling via Palladium–Protein Oxidative Addition Complexes from Cysteine Residues

2020, Publications

Efficient Flow Synthesis of Human Antimicrobial Peptides

2020, Publications

A novel, safe, fast and efficient treatment for Her2‐positive and negative bladder cancer utilizing an EGF‐anthrax toxin chimera

2019, Publications

Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism

2020, Publications

Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy

2020, Publications

Quantifying residue-specific conformational dynamics of a highly reactive 29-mer peptide

2020, Publications

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

2019, Publications

Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

2019, Publications

Studies on a landscape of perfluoroaromatic-reactive peptides

2019, Publications

In-solution enrichment identifies peptide inhibitors of protein–protein interactions

2019, Publications

Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner

2019, Publications

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

2019, Publications

Arylation Chemistry for Bioconjugation

2019, Publications

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

2019, Publications

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

2018, Publications

Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

2018, Publications

Antibody–Bactericidal Macrocyclic Peptide Conjugates To Target Gram‐Negative Bacteria

2018, Publications

Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

2018, Publications

Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability

2018, Publications

Xenoprotein engineering via synthetic libraries

2018, Publications

Amide-forming chemical ligation via O-acyl hydroxamic acids

2018, Publications

Designing Well-Structured Cyclic Pentapeptides Based on Sequence–Structure Relationships

2018, Publications

Site‐Selective Cysteine–Cyclooctyne Conjugation

2018, Publications

Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides

2018, Publications

Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

2018, Publications

Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking

2018, Publications

Discovery of a 29-Amino-Acid Reactive Abiotic Peptide for Selective Cysteine Arylation

2018, Publications

A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

2017, Publications

Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

2017, Publications

Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

2017, Publications

Heterochiral Knottin Protein: Folding and Solution Structure

2017, Publications

Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries

2017, Publications

Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

2017, Publications

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

2017, Publications

Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase

2017, Publications

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

2017, Publications

A fully automated flow-based approach for accelerated peptide synthesis

2017, Publications

Palladium-Mediated Arylation of Lysine in Unprotected Peptides

2017, Publications

Salt Effect Accelerates Site-Selective Cysteine Bioconjugation

2016, Publications

d-Amino Acid Scan of Two Small Proteins

2016, Publications

Nitrogen Arylation for Macrocyclization of Unprotected Peptides

2016, Publications

Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin

2016, Publications

Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates

2016, Publications

C-Terminal Modification of Fully Unprotected Peptide Hydrazides via in Situ Generation of Isocyanates

2016, Publications

Macrocyclization of Unprotected Peptide Isocyanates

2016, Publications

A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis

2016, Publications

π-Clamp-mediated cysteine conjugation

2015, Publications

A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway

2015, Publications

Organometallic palladium reagents for cysteine bioconjugation

2015, Publications

An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides.

2015, Publications

Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen

2015, Publications

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

2015, Publications

Atomic structure of anthrax protective antigen pore elucidates toxin translocation.

2015, Publications

Total Synthesis and Biochemical Characterization of Mirror Image Barnase

2015, Publications

Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs

2015, Publications

Delivery of mirror image polypeptides into cells

2014, Publications

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen

2014, Publications

Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides

2014, Publications

Flow-Based Enzymatic Ligation via Sortase A

2014, Publications

Rapid Total Synthesis of DARPin pE59 and Barnase

2014, Publications

Rapid Flow-Based Peptide Synthesis

2014, Publications

Convergent Diversity-Oriented Side-Chain Macrocyclization Scan for Unprotected Polypeptides

2014, Publications

Enzymatic “Click” Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase

2013, Publications

Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance.

2013, Publications

A Perfluoroaryl-Cysteine Chemistry Approach to Unprotected Peptide Stapling

2013, Publications

Three Dimensional Structure of the Anthrax Toxin Translocon–lethal Factor Complex by Cryo-electron Microscopy

2013, Publications

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

2013, Publications

Assembly of Anthrax Toxin Pore: Lethal-factor Complexes into Lipid Nanodiscs.

2013, Publications

Protein Thioester Synthesis Enabled By: Sortase

2012, Publications